This Contec Healthcare Cleanovators Panel focused on addressing key questions from the audience regarding contamination risks in healthcare settings, particularly in relation to hazardous drugs (HDs). Attendees learned about the critical contamination points, such as doorknobs and the importance of proper cleaning protocols in negative pressure rooms. The discussion emphasized the need for robust cleaning methods and adherence to specific PPE requirements to mitigate cross-contamination risks. Participants were encouraged to observe and evaluate cleaning practices, as well as to provide feedback for future events. The session concluded with appreciation for the attendees' engagement and a reminder of the upcoming ASHP show for further discussions.